NicotinamideN-methyl transferase (NNMT) gene polymorphisms and risk for spina bifida
نویسندگان
چکیده
منابع مشابه
CHKA and PCYT1A gene polymorphisms, choline intake and spina bifida risk in a California population
BACKGROUND Neural tube defects (NTDs) are among the most common of all human congenital defects. Over the last two decades, accumulating evidence has made it clear that periconceptional intake of folic acid can significantly reduce the risk of NTD affected pregnancies. This beneficial effect may be related to the ability of folates to donate methyl groups for critical physiological reactions. C...
متن کاملSpina bifida and sexuality.
OBJECTIVE To evaluate sexual function amongst adult individuals with spina bifida and to register their subjective satisfaction with their sexual life and relationships. SETTING Department for Spinal Cord Injuries, East Denmark. STUDY DESIGN AND METHODS Cohort study. Medical record information, neurological examination, personal interview, Functional Independence Measure (FIMTM), Medical Ou...
متن کاملSpina Bifida and Rehabilitation
Spina bifida (SB) is the incomplete closure of the posterior elements of the vertebrae due to a developmental disorder. Among the causes of childhood disability, SB is the second most common cause after cerebral palsy. Generally, secondary motor neuron findings are seen below the lesion.The ambulation grade and the orthoses used by patients vary according to the level of the lesion. SB patients...
متن کاملRisk factors for latex sensitization in children with spina bifida.
BACKGROUND Children with spina bifida represent the major risk group for latex sensitization. PURPOSE To determine the prevalence of latex sensitization in these children and to identify risk factors. MATERIAL AND METHODS We studied 57 patients with spina bifida. The mean age was 5.6 years and the male/female ratio was 0.8/1. In all patients a questionnaire, skin prick test (SPT) with latex...
متن کاملMutated methylenetetrahydrofolate reductase as a risk factor for spina bifida.
Periconceptional folate supplementation reduces the risk of neural-tube defects. We studied the frequency of the 677C-->T mutation in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene in 55 patients with spina bifida and parents of such patients (70 mothers, 60 fathers). 5% of 207 controls were homozygous for the 677C-->T mutation compared with 16% of mothers, 10% of fathers, and 13% of...
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ژورنال
عنوان ژورنال: Birth Defects Research Part A: Clinical and Molecular Teratology
سال: 2008
ISSN: 1542-0752,1542-0760
DOI: 10.1002/bdra.20474